NMR-BIO is pleased to offer now customized NMR services ranging from the production of labelled proteins to the acquisition and analysis of high field NMR data. Our engineers are experts in the production of proteins & RNAs uniformly and specifically labeled with stable isotopes (13C, 15N, and 2H) using in vivo and in vitro expression systems.

For high molecular weight systems, we offer expert production and/or NMR analysis of methyl specific labelled proteins. To characterise your samples and collect structural or dynamics information our experts have access to state-of-the-art NMR spectrometers operating at 1H frequency ranging from 600 MHz to 950 MHz.

Examples of our services:

Protein sample production (in E. coli, insect cells and Cell-Free):

  • [2H,13C,15N]-uniform labeling of proteins;
  • 13CH3 specific labeling of large proteins;
  • Production & analysis of mutant libraries (e.g. for NMR spectra assignment).

  • Structural studies:

  • High field NMR data acquisition (e.g. nD, NOESY, SOFAST, BEST);
  • NMR Protein control quality (e.g. folding, compactness, dynamic using natural abundance or stable isotope enrichment);
  • NMR studies of protein (e.g. interactions, backbone and sidechain assignment, structure calculation and relaxation characterisation);
  • EM Protein control quality (e.g. homogeneity);
  • NMR studies of large protein assemblies (e.g. interactions, methyl groups assignment, relaxation characterisation);
  • EM studies of large protein assemblies (e.g. structure calculation).

    For more information about our services or to receive a specific quotation corresponding to your project, please contact us by email at: