We unlock the full potential of antibody research with custom antibody services.
At NMR-Bio, we specialize in NMR spectroscopy and recombinant antibody production to support the structural and functional characterization of therapeutic antibodies. Our comprehensive services cover the production of labeled and unlabeled recombinant antibodies as well as antibody fragments in eukaryotic cells systems. We offer high-resolution structural analysis and interaction studies to ensure precise insights into the affinity and specificity of antibodies for drug development and diagnostics.
Whether you require recombinant antibodies or antibody fragments for your structural characterization, we deliver high-quality samples with unmatched specificity.
At NMR-Bio, we support your project from the antibody production and purification to the final quality control, ensuring you receive antibodies that meet the highest standards of research and therapeutic application. Our team of antibody experts works closely with you throughout the entire process, ensuring that every antibody we produce is fully optimized for your research goals.
Our custom antibody production & development services.
At NMR-Bio, we specialize in custom antibody development and structural analysis to support the development of therapeutic antibodies. Our services provide comprehensive solutions for monoclonal antibody production, along with NMR structural and interaction studies. Whether you are working on antibody design or antigen development, we ensure that our antibody development services align with your research goals and deliver optimal results.
Custom antibody & Antibody fragment production
NMR-Bio provides custom production of monoclonal antibodies, tailored for NMR research, antigen design, and other functional applications.
Production of Recombinant Antibodies & Fragments (Fab, Fc, etc.)
We produce recombinant antibodies and fragments using a variety of expression systems (CHO, E. coli, cell-free systems) to meet your specific needs. Our services include:
- High-yield production and purification of full-length antibodies and fragments.
- Optimization for high solubility and stability, ensuring your antibodies are ready for assay development.
Additionally, we handle the production of soluble antigens, optimized for antibody generation services.
Isotope-Labeled Antibody & Fragment Production & Fragments (Fab, Fc, etc.)
For NMR-based studies, we offer custom isotopic labeling services, including:
- Uniform ¹⁵N, ¹³C, and ²H labeling of antibody fragments for structural studies.
- Specific methyl labeling of key residues (Ile, Leu, Val, Met, Thr, Ala) in CHO-expressed antibodies for enhanced NMR analysis.
Whether you require labeled or unlabeled antibodies and fragments, our production platforms deliver high-quality proteins optimized for your studies.
Advanced antibody structural analysis
High-resolution structural characterization
Using high-field NMR spectroscopy, we have access to atomic fingerprint of antibodies and fragments, allowing us to :
- Identify conformational changes.
- Analyze structural flexibility and dynamics.
- Assess the impact of mutations on protein stability.
Epitope mapping for antibody-antigen interactions
Understanding antibody-target interactions is critical for drug development and vaccine design. Using solution-state NMR, we provide high-resolution epitope mapping, identifying binding sites and interaction hotspots.
Aggregation and stability studies
We specialize in studying antibody fragments (such as Fab or Fc), providing:
- High-resolution structural insights.
- Comparative studies between full-length and fragment-based antibodies.
- Stability and solubility assessments for therapeutic applications.
Fragment-based analysis
We help detect early-stage aggregation processes and structural modifications leading to instability, which allows us to optimize long-term antibody formulation and improve batch stability.
Batch-to-Batch consistency analysis
For biopharmaceutical companies, ensuring batch consistency is critical. NMR-Bio acquires 2D NMR spectra at 13C natural abundance on high-field NMR spectrometers to monitor consistency across batches.
Get in touch to accelerate your drug discovery process.
Contact NMR-Bio today to discuss your custom antibody production, structural analysis, and antibody development needs. Our recombinant antibodies are tailored to meet your specific research requirements with high-quality results. From antibody production and purification to antibody structural studies, our experts are here to guide your custom antibody project to success.